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foxo inhibition  (Selleck Chemicals)


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    Selleck Chemicals foxo inhibition
    UroA-induced FOXO1 transcriptional activity is mitophagy independent. A, Quantification of CD62 L expression level in CD8 + T treated with UroA (5 µmol/L) and in presence of FOXO1 inhibitor <t>(Foxo</t> inh 50 nmol/L) for 48 hours in vitro . Values are expressed as fold change compare with control condition. B, Schematic representation of FOXO1 <t>inhibition</t> in vivo analyzed in C. C, Quantification of naïve CD8 + T population isolated from mice fed with UroA diet and treated with Foxo inh. Values are expressed as fold change compare with control condition (left). Quantification of CD62 L expression level in CD8 + T isolated from mice fed with UroA diet and treated with Foxo inh (right) for 48 hours in vitro . D, Expression level of PGC1α in CD8 + T treated with UroA (5 µmol/L) for 48 hours in vitro . E, Quantification of Mito-QC CD8 + T cells engaging mitophagy under indicated condition in vitro for 24 hours (UroA 5 µmol/L, Foxo inh 50 nmol/L). Quantification of mCherry/GFP ratio from E (right). F, Expression level of PGC1α in CD8 + T cells cultured in presence of Foxo inh (50 nmol/L) or mitophagy blocker (mDivi 10 µmol/L) for 48 hours in vitro . Data are mean ± SEM. Each dot represents a biological replicate. In A, sample size n = 9. In C, sample size n = 8. In D, sample size n = 6. In E, sample size n = 7. In F, sample size n = 3. Data were analyzed by two-sided Student t or ANOVA test followed by multiple comparison test (*, P < 0.05; **, P < 0.01; ****, P < 0.0001). Representative results of at least two independent experiments or two pooled experiments.
    Foxo Inhibition, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 61 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/foxo inhibition/product/Selleck Chemicals
    Average 94 stars, based on 61 article reviews
    foxo inhibition - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Urolithin-A Promotes CD8 + T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation"

    Article Title: Urolithin-A Promotes CD8 + T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation

    Journal: Cancer Research Communications

    doi: 10.1158/2767-9764.CRC-24-0022

    UroA-induced FOXO1 transcriptional activity is mitophagy independent. A, Quantification of CD62 L expression level in CD8 + T treated with UroA (5 µmol/L) and in presence of FOXO1 inhibitor (Foxo inh 50 nmol/L) for 48 hours in vitro . Values are expressed as fold change compare with control condition. B, Schematic representation of FOXO1 inhibition in vivo analyzed in C. C, Quantification of naïve CD8 + T population isolated from mice fed with UroA diet and treated with Foxo inh. Values are expressed as fold change compare with control condition (left). Quantification of CD62 L expression level in CD8 + T isolated from mice fed with UroA diet and treated with Foxo inh (right) for 48 hours in vitro . D, Expression level of PGC1α in CD8 + T treated with UroA (5 µmol/L) for 48 hours in vitro . E, Quantification of Mito-QC CD8 + T cells engaging mitophagy under indicated condition in vitro for 24 hours (UroA 5 µmol/L, Foxo inh 50 nmol/L). Quantification of mCherry/GFP ratio from E (right). F, Expression level of PGC1α in CD8 + T cells cultured in presence of Foxo inh (50 nmol/L) or mitophagy blocker (mDivi 10 µmol/L) for 48 hours in vitro . Data are mean ± SEM. Each dot represents a biological replicate. In A, sample size n = 9. In C, sample size n = 8. In D, sample size n = 6. In E, sample size n = 7. In F, sample size n = 3. Data were analyzed by two-sided Student t or ANOVA test followed by multiple comparison test (*, P < 0.05; **, P < 0.01; ****, P < 0.0001). Representative results of at least two independent experiments or two pooled experiments.
    Figure Legend Snippet: UroA-induced FOXO1 transcriptional activity is mitophagy independent. A, Quantification of CD62 L expression level in CD8 + T treated with UroA (5 µmol/L) and in presence of FOXO1 inhibitor (Foxo inh 50 nmol/L) for 48 hours in vitro . Values are expressed as fold change compare with control condition. B, Schematic representation of FOXO1 inhibition in vivo analyzed in C. C, Quantification of naïve CD8 + T population isolated from mice fed with UroA diet and treated with Foxo inh. Values are expressed as fold change compare with control condition (left). Quantification of CD62 L expression level in CD8 + T isolated from mice fed with UroA diet and treated with Foxo inh (right) for 48 hours in vitro . D, Expression level of PGC1α in CD8 + T treated with UroA (5 µmol/L) for 48 hours in vitro . E, Quantification of Mito-QC CD8 + T cells engaging mitophagy under indicated condition in vitro for 24 hours (UroA 5 µmol/L, Foxo inh 50 nmol/L). Quantification of mCherry/GFP ratio from E (right). F, Expression level of PGC1α in CD8 + T cells cultured in presence of Foxo inh (50 nmol/L) or mitophagy blocker (mDivi 10 µmol/L) for 48 hours in vitro . Data are mean ± SEM. Each dot represents a biological replicate. In A, sample size n = 9. In C, sample size n = 8. In D, sample size n = 6. In E, sample size n = 7. In F, sample size n = 3. Data were analyzed by two-sided Student t or ANOVA test followed by multiple comparison test (*, P < 0.05; **, P < 0.01; ****, P < 0.0001). Representative results of at least two independent experiments or two pooled experiments.

    Techniques Used: Activity Assay, Expressing, In Vitro, Control, Inhibition, In Vivo, Isolation, Cell Culture, Comparison



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    UroA-induced FOXO1 transcriptional activity is mitophagy independent. A, Quantification of CD62 L expression level in CD8 + T treated with UroA (5 µmol/L) and in presence of FOXO1 inhibitor <t>(Foxo</t> inh 50 nmol/L) for 48 hours in vitro . Values are expressed as fold change compare with control condition. B, Schematic representation of FOXO1 <t>inhibition</t> in vivo analyzed in C. C, Quantification of naïve CD8 + T population isolated from mice fed with UroA diet and treated with Foxo inh. Values are expressed as fold change compare with control condition (left). Quantification of CD62 L expression level in CD8 + T isolated from mice fed with UroA diet and treated with Foxo inh (right) for 48 hours in vitro . D, Expression level of PGC1α in CD8 + T treated with UroA (5 µmol/L) for 48 hours in vitro . E, Quantification of Mito-QC CD8 + T cells engaging mitophagy under indicated condition in vitro for 24 hours (UroA 5 µmol/L, Foxo inh 50 nmol/L). Quantification of mCherry/GFP ratio from E (right). F, Expression level of PGC1α in CD8 + T cells cultured in presence of Foxo inh (50 nmol/L) or mitophagy blocker (mDivi 10 µmol/L) for 48 hours in vitro . Data are mean ± SEM. Each dot represents a biological replicate. In A, sample size n = 9. In C, sample size n = 8. In D, sample size n = 6. In E, sample size n = 7. In F, sample size n = 3. Data were analyzed by two-sided Student t or ANOVA test followed by multiple comparison test (*, P < 0.05; **, P < 0.01; ****, P < 0.0001). Representative results of at least two independent experiments or two pooled experiments.
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    Image Search Results


    UroA-induced FOXO1 transcriptional activity is mitophagy independent. A, Quantification of CD62 L expression level in CD8 + T treated with UroA (5 µmol/L) and in presence of FOXO1 inhibitor (Foxo inh 50 nmol/L) for 48 hours in vitro . Values are expressed as fold change compare with control condition. B, Schematic representation of FOXO1 inhibition in vivo analyzed in C. C, Quantification of naïve CD8 + T population isolated from mice fed with UroA diet and treated with Foxo inh. Values are expressed as fold change compare with control condition (left). Quantification of CD62 L expression level in CD8 + T isolated from mice fed with UroA diet and treated with Foxo inh (right) for 48 hours in vitro . D, Expression level of PGC1α in CD8 + T treated with UroA (5 µmol/L) for 48 hours in vitro . E, Quantification of Mito-QC CD8 + T cells engaging mitophagy under indicated condition in vitro for 24 hours (UroA 5 µmol/L, Foxo inh 50 nmol/L). Quantification of mCherry/GFP ratio from E (right). F, Expression level of PGC1α in CD8 + T cells cultured in presence of Foxo inh (50 nmol/L) or mitophagy blocker (mDivi 10 µmol/L) for 48 hours in vitro . Data are mean ± SEM. Each dot represents a biological replicate. In A, sample size n = 9. In C, sample size n = 8. In D, sample size n = 6. In E, sample size n = 7. In F, sample size n = 3. Data were analyzed by two-sided Student t or ANOVA test followed by multiple comparison test (*, P < 0.05; **, P < 0.01; ****, P < 0.0001). Representative results of at least two independent experiments or two pooled experiments.

    Journal: Cancer Research Communications

    Article Title: Urolithin-A Promotes CD8 + T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation

    doi: 10.1158/2767-9764.CRC-24-0022

    Figure Lengend Snippet: UroA-induced FOXO1 transcriptional activity is mitophagy independent. A, Quantification of CD62 L expression level in CD8 + T treated with UroA (5 µmol/L) and in presence of FOXO1 inhibitor (Foxo inh 50 nmol/L) for 48 hours in vitro . Values are expressed as fold change compare with control condition. B, Schematic representation of FOXO1 inhibition in vivo analyzed in C. C, Quantification of naïve CD8 + T population isolated from mice fed with UroA diet and treated with Foxo inh. Values are expressed as fold change compare with control condition (left). Quantification of CD62 L expression level in CD8 + T isolated from mice fed with UroA diet and treated with Foxo inh (right) for 48 hours in vitro . D, Expression level of PGC1α in CD8 + T treated with UroA (5 µmol/L) for 48 hours in vitro . E, Quantification of Mito-QC CD8 + T cells engaging mitophagy under indicated condition in vitro for 24 hours (UroA 5 µmol/L, Foxo inh 50 nmol/L). Quantification of mCherry/GFP ratio from E (right). F, Expression level of PGC1α in CD8 + T cells cultured in presence of Foxo inh (50 nmol/L) or mitophagy blocker (mDivi 10 µmol/L) for 48 hours in vitro . Data are mean ± SEM. Each dot represents a biological replicate. In A, sample size n = 9. In C, sample size n = 8. In D, sample size n = 6. In E, sample size n = 7. In F, sample size n = 3. Data were analyzed by two-sided Student t or ANOVA test followed by multiple comparison test (*, P < 0.05; **, P < 0.01; ****, P < 0.0001). Representative results of at least two independent experiments or two pooled experiments.

    Article Snippet: For FOXO inhibition experiments, mice were intraperitoneally injected with FOXO inhibitor AS1842856 (S8222, Selleckchem) at 10 mg/kg as previously described twice per week ( ).

    Techniques: Activity Assay, Expressing, In Vitro, Control, Inhibition, In Vivo, Isolation, Cell Culture, Comparison